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KMID : 0620920000320030101
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Experimental & Molecular Medicine
2000 Volume.32 No. 3 p.101 ~ p.109
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The mechanism of phospholipase C-γ1 regulation
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Pann Ghill Suh/yung Jong Kim
Eui Kyung Kim/Sung Ho Ryu/Pann Ghill Suh
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Abstract
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Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-γ1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-γ1.
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KEYWORD
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phospholipase C, protein kinase C,
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